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Factsheets

Benign ethnic neutropenia

Benign ethnic neutropenia (BEN) can be defined as: ‘The occurrence of neutropenia, defined by normative data in white populations, in individuals of other ethnic groups who are otherwise healthy and who do not have repeated or severe infections’.

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Gastrointestinal side-effects

This information sheet will cover the following side-effects: nausea, vomiting, dysphagia, dry mouth and parotid gland enlargement.

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Red alert management

The most well recognised side-effects of clozapine are neutropenia, defined as a neutrophil count of less than 1.5 x 109/L and agranulocytosis which is a neutrophil count of less than 0.5 x 109/L.

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Optimising Treatment Management with Clozaril

This factsheet covers initiating treatment with Clozaril…

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Clozapine and cardiovascular events

Tachycardia typically occurs in the first few weeks of treatment and it may persist in some patients. It is usually dose-related.

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Neurological side effects with Clozaril

Clozaril lowers the seizure threshold in a dose-dependent manner…

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Lifestyle Considerations with Clozaril

This factsheet will cover hypersalivation with Clozaril, weight gain with Clozaril….

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Materials

What to expect from Clozaril®

This booklet is intended only for patients who have been prescribed Clozaril® and/or their family/carers.

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Clozaril® leavepiece

NICE defines ‘treatment resistance’ in schizophrenia patients as the lack of satisfactory clinical improvement following sequential treatment with at least two different antipsychotic drugs, including at least one second-generation (atypical) antipsychotic.

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CLZ-2022-0100 May 2023

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This website is intended for UK and Ireland healthcare professionals only.

Clozaril is indicated in treatment-resistant schizophrenic patients and in schizophrenia patients who have severe, untreatable neurological adverse reactions to other antipsychotic agents, including atypical antipsychotics.

Treatment resistance is defined as a lack of satisfactory clinical improvement despite the use of adequate doses of at least two different antipsychotic agents, including an atypical antipsychotic agent, prescribed for adequate duration.

Clozaril is also indicated in psychotic disorders occurring during the course of Parkinson's disease, in cases where standard treatment has failed.

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Reporting of adverse reactions:

UK: Please continue to report suspected side effects to the MHRA through the Yellow Card Scheme. Please report all suspected side effects that are serious or result in harm. Serious reactions are those that are fatal, life-threatening, disabling or incapacitating, those that cause a congenital abnormality or result in hospitalisation, and those that are considered medically significant for any other reason. It is easiest and quickest to report side effects online via the Yellow Card website – https://yellowcard.mhra.gov.uk/ or via the Yellow Card app available from the Apple App Store or Google Play Store. Alternatively, prepaid Yellow Cards for reporting are available by writing to FREEPOST YELLOW CARD (no other address details necessary); by emailing yellowcard@mhra.gov.uk; at the back of the British National Formulary (BNF); by telephoning the Commission on Human Medicines (CHM) free phone line: 0800-731-6789; or by downloading and printing a form from the Yellow Card website.

Ireland: Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product.

Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system HPRA Pharmacovigilance, Website: www.hpra.ie.

Adverse reactions/events should also be reported to the marketing authorisation holder at email address: CPMS@Viatris.com

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